摘要
研究了桑黄粗多糖(PL)对高转移卵巢癌细胞(HO-8910PM)和乳腺癌细胞(Bcap-37)增殖和转移相关能力的影响及其作用的机制.研究结果表明,桑黄粗多糖能有效抑制裸鼠移植瘤的生长,抑制率为65.37%;对离体培养的HO-8910PM和Bcap-37细胞的抑制率分别达到15.53%和23.81%;500μg/ml PL作用于HO-8910PM细胞96h可诱导其凋亡,通过细胞周期G0/G1期阻滞而抑制细胞增殖和诱导细胞凋亡;PL能显著抑制HO-8910PM的黏附、侵袭和迁移等肿瘤转移相关能力.桑黄粗多糖具有抑制肿瘤细胞增殖及肿瘤转移的作用.
This paper studied the effects and mechanism of polysaccharides extracted from Phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37. The results showed PL inhibited the growth of Bcap37 tumor in vivo by 65.37%, while inhibited the proliferation of HO-8910PM and Bcap-37 in vitro respectiyely by 15.53% and 23. 81%. PL induced G0/G1 phase arrest and 500 μg/ml PL induced HO-8910PM cell apoptosis after 96 h treatments. PL may act as a direct inhibitor of HO-8910PM cell adhesion, invasion and migration which are related to tumor metastasis. The result indicated that PL has inhibitory effect on tumor cell proliferation and metastasis.
出处
《华东师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2008年第2期78-84,共7页
Journal of East China Normal University(Natural Science)
关键词
桑黄多糖
高转移卵巢癌细胞
乳腺癌细胞
增殖
转移
polysaccharides from Phellinus linteus
HO-8910PM
Bcap-37, proliferation
metastasis
