摘要
醛与伯胺缩合形成希夫碱，乙腈在二异丙基氨基锂的强碱性条件下形成负离子，对希夫碱中间体进行亲核加成，以78％～100％的总收率获得β-氨基腈类化合物。提供了一条合成伊氨基酸衍生物的有效合成途径。获得的产物β-氨基腈中，新化合物的结构经过IR、Ms、^1H NMR、^13C NMR及元素分析确证。
Schiff bases were prepared from aldehydes and primary amines. Under strong basic conditions of LDA,anion formed from acetonitrile underwent nucleophlic attack toward Schiff base intermidiates.β-A-mino nitriles were thus conveniently obtained in 78%-100% yields. This method render an effective synthetic route to β-amino acid derivatives. Of β-amino nitrile products obtained,new compounds were characterized by IR, MS, ^1H NMR, ^13 C NMR and elemental analysis.
出处
《应用化工》
CAS
CSCD
2008年第3期298-299,共2页
Applied Chemical Industry
关键词
β-氨基腈
希夫碱
乙腈
合成
β-amino nitrile
Schiff base
acetonitrile
synthesis
