摘要
目的探讨乳腺癌非哨兵淋巴结(non-sentinellymphnode,NSN)转移预测的临床因素。方法回顾该科近2年来230例乳腺癌患者行哨兵淋巴结活检(sentinellymphnodebiopsy,SLNB),后行腋窝淋巴结清扫术(axillarylymphnodedissection,ALND)。有哨兵淋巴结(sentinellymphnode,SN)转移的94例,分析其中非哨兵淋巴结(NSN)转移的患者与临床因素的关系。结果SN有转移的94例患者,67例(72.27%)有NSN转移;原发肿瘤的大小(P<0.01),SN转移的个数(P<0.05),组织学病理分级(P<0.05)是预测NSN转移的指标。将3个因素联合起来预测NSN转移可达到94.12%(16/17)(P>0.05);而患者年龄,肿瘤生长位置、病理类型、ER、PR、C-erbB-2(Her-2/neu)、P53、nm23表达与否对NSN转移预测无统计学意义(P>0.05)。结论乳腺癌原发病灶的大小,SN转移的个数,组织学病理分级或3个因素联合分析对预测NSN的转移有重要意义。
[Objective] To investigate the predictive factors of non-sentinel lymph node （NSN） metastases in women with invasive breast cancer. [Methods] Aprospective data was analyzed and enrolled patients （n = 230） who underwent sentinel lymph node biopsy （SLNB） follow axillary lymph node dissection （ALND） for invasive breast cancer in the recent 2 years. 90 （40.86%） patients had one or more positive SLNs and were analyzed to determine factors that predicted additional positive axillary nodes. [Results] Of the 94 patients with positive SLN, 67 （71.27%） patients had additional metastasis in NSN. The significant variables that predicted NSN metastasis were tumor size （P 〈0.01）, number of positive SLN （P 〈0.05）, and unclear grade （P 〈0.05）. The accuracy of the combination of the three factors in predicting NSN metastases was 94.12% （16/17） （P 〉0.05）. The age, tumor location, histologic type, estrogen and progesterone receptors （ER, PR）, C-erbB-2 （Her-2/neu）, P53, nm23 status had no effect on NSN metastases （P 〉0.05）. [Conclusion] Tumor size, number of positive SLN, unclear grade and the combination of those three factors are important in predicting NSN metastasis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第5期608-610,共3页
China Journal of Modern Medicine
关键词
乳腺癌
哨兵淋巴结
转移
breast cancer
sentinel lymph node
metastases
