摘要
目的分析地方性克汀病的病因相关因素。方法选取内蒙古自治区呼和浩特市林格尔县、乌兰察布盟凉城县、兴安盟突泉县和赤峰市松山区为调查地区,进行克汀病病因相关因素的研究。结果调查地区地方性克汀病人一级亲属、二级亲属和三级亲属患病率分别为16.2%、3.5%和1.5%,加权平均遗传度为65.4%±4.2%,克汀病病区病人血清中铜、硒、锌含量明显低于非病区正常人,病区主要粮食中铁、硒、锌的含量低于非病区,病区生活饮用水中铜、硒的含量明显低于非病区。结论研究结果表明,地方性克汀病有明显的家庭聚集性。病因除公认的环境缺碘因素外,遗传因素和其它环境因素也起重要作用。
Objective Analyses on the related factors of pathogeny of endemic cretinism. Method The study was conducted in Inner Mongolia Autonomous Region. Helingeer couny of Huhohot city, Liangcheng county of Wulanchabu city, Tuquan county of Xing＇an prefecture and Songshan district of Chifeng city were selected as the research area for the study. The local investigation included family tree analysis to search the heritability of cretinism. Results Cases of endemic cretinism have the trend of family cluster significantly. The prevalence rates of cretinism were 16.2%, 3.5% and 1.5% for the first degree kinsfolk, the second degree kinsfolk and the third degree kinsfolk respectively. The weighted average of the heritability was 65.4% ± 4.2%. Conclusion The result showed there was a phenomenon of family clustering existed among endemic cretinism patients. Except the factor of iodine deficiency in the surrounding environment, the heredity factors and other environmental factors also play important role in the pathogeny of endemic cretinism.
出处
《中国地方病防治》
北大核心
2008年第2期98-100,共3页
Chinese Journal of Control of Endemic Diseases
关键词
家庭聚集性
遗传度
微量元素
遗传因素
环境因素
Family clustering
Heritability
Microelement
Heredity factors
Environment factors
