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低分子量地黄多糖对p53基因表达的影响 被引量:67

Effects of low molecular weight Rehmannia glutinosa polysaccharides on p53 gene expression
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摘要 研究低分子量地黄多糖(LRPS)对p53基因表达的影响.方法:利用定量PCR的方法检测p53基因表达的水平.结果:LRPS在最适抗肿瘤有效剂量20和40mg·kg-1条件下,Lewis肺癌组织内p53基因的表达水平分别是152和148,对照组为046,环磷酰胺组为160.LRPS能使Lewis肺癌组织内p53基因的表达明显增加.结论:LRPS对抗癌基因p53表达的影响是其抗肿瘤作用的机制之一. AIM: To study the effect of low molecular weight Rehmannia glutinosa polysaccharides (LRPS) on p53 gene expression. METHODS: The level of p53 gene expression was determined by quantitative polymerase chain reaction and autoradiography. RESULTS: The levels of p53 mRNA in Lewis lung cancer tissue were 0 46, 1 52, 1 48, and 1 60 respectively after saline, LRPS 20 and 40 mg·kg -1 , and cyclophosphamide 10 mg·kg -1 , which were the effective doses inhibiting the growth of tumor tissue cells in vivo . LRPS markedly increased p53 gene expression. CONCLUSION: LRPS effect on p53 gene expression is one of the mechanisms of antitumor activity.
出处 《中国药理学报》 CSCD 1997年第5期471-474,共4页 Acta Pharmacologica Sinica
关键词 地黄 多糖 P53基因 聚合酶链反应 Rehmannia glutinosa polysaccharides cyclophosphamide phytogenic antineoplastic agents lung neoplasms p53 genes polymerase chain reaction autoradiography
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参考文献2

  • 1Liu F J,中国药学杂志,1995年,30卷,增刊,87页
  • 2Chen L Z,中国药理学与毒理学杂志,1993年,7卷,153页

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