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Colorectal cancer risk in Crohn's disease 被引量:2

Colorectal cancer risk in Crohn’s disease
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摘要 There is recognized increased risk for colorectal cancer in patients with inflammatory bowel disease, particularly in long-standing and extensive ulcerative colitis. There also appears to be an increased rate of intestinal cancer in Crohn's disease, including both colon and small bowel sites. In Crohn's disease, evidence suggests that detection of colorectal cancer may be delayed with a worse progno-sis. Some risk factors for cancer in Crohn's disease include the extent of inflammatory change within the colon and the presence of bypassed or excluded segments, inclu-ding rectal "stump" cancer. In addition, the risk for other types of intestinal neoplasms may be increased in Crohn's disease, including lymphoma and carcinoid tumors. Earlier detection of colorectal cancer based on colonoscopy scre-ening and surveillance may be achieved but, to date, this has not translated into a positive survival benefit. Moreo-ver, newer staining methods and evolving micro-endos-copic techniques show promise, but have not significantly altered management. Future research should focus on development of molecular or other bio-markers that might predict future dysplasia or cancer development in Crohn's disease. There is recognized increased risk for colorectal cancer in patients with inflammatory bowel disease, particularly in long-standing and extensive ulcerative colitis. There also appears to be an increased rate of intestinal cancer in Crohn's disease, including both colon and small bowel sites. In Crohn's disease, evidence suggests that detection of colorectal cancer may be delayed with a worse prognosis. Some risk factors for cancer in Crohn's disease include the extent of inflammatory change within the colon and the presence of bypassed or excluded segments, inclu- ding rectal "stump" cancer. In addition, the risk for other types of intestinal neoplasms may be increased in Crohn's disease, including lymphoma and carcinoid tumors. Earlier detection of colorectal cancer based on colonoscopy screening and surveillance may be achieved but, to date, this has not translated into a positive survival benefit. Moreover, newer staining methods and evolving micro-endoscopic techniques show promise, but have not significantly altered management. Future research should focus on development of molecular or other bio-markers that might predict future dysplasia or cancer development in Crohn's disease.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第12期1810-1811,共2页 世界胃肠病学杂志(英文版)
关键词 Colon cancer Crohn's disease SURVEILLANCE Small bowel cancer 结肠癌 风险 Crohn疾病 监视 小肠癌
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  • 8Bohuslav Melichar M.D., Ph.D.,Jan Bure? M.D., Ph.D.,Karel Dědi? M.D., Ph.D..Anorectal Carcinoma After Infliximab Therapy in Crohn’s Disease: Report of a Case[J]. Diseases of the Colon & Rectum . 2006 (8)
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  • 10Thomas Nicholson M.D.,Guy R. Orangio M.D.,David Brandenburg M.D., F.A.C.G.,Douglas C. Wolf M.D., F.A.C.G.,E. Earl Pennington M.D..Crohn’s Colitis Presenting With Node-Negative Colon Cancer and Liver Metastasis After Therapy With Infliximab: Report of Two Cases[J]. Diseases of the Colon & Rectum . 2005 (8)

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