摘要
目的:探讨GM1治疗新生儿缺氧缺血性脑病的疗效及对血清NSE水平的影响。方法:72例新生儿缺氧缺血性脑病患儿,随机分为GM1治疗组40例和常规治疗组32例,并选取正常新生儿20例作为对照组。比较治疗前后两组CT检测值与新生儿行为神经评分;并比较治疗组及正常对照组分别在生后24h内及药物治疗7d后抽血检测血清NSE水平。结果:①治疗后CT检查值,两组与治疗前比较,差异有显著性(t=3.11,P<0.05);治疗一疗程时两组间比较,差异无统计学意义(t=1.24,P>0.05),出生后28dGM1治疗组明显高于常规治疗组(t=3.57,P<0.05)。两组患儿治疗后一疗程、出生后28dNBNA评分较治疗前有明显改善,且GM1治疗组优于常规治疗组(t=2.01,P<0.05)。②GM1治疗组其临床症状和体征改善明显优于常规治疗组(P<0.01)。③HIE患儿轻度组NSE水平与对照组比较无显著性差异(P>0.05),中、重度NSE水平与对照组比较显著升高,以重度HIE组升高明显(P<0.01)。④GM1治疗组与常规治疗组治疗后血清NSE浓度较治疗前明显降低,其中GM1治疗组降低幅度明显高于常规治疗组(P<0.01)。结论:GM1在HIE患儿早期应用可稳定神经元细胞膜,减少细胞凋亡,从而减少NSE的释放,发挥神经保护作用。
Objective：To investigate the curative effect and infection on NSE level of neonatal hypoxic-ischemic en- cephalopathy infants with GM 1.Methods：72 cases were randomly divided into two groups,40 cases in GM 1 treatment group and 32 cases in routine treatment group. We selected 20 health infants as contrast group. The concentration of blood serum NSE was examined in treatment and contrast group after birth and 7 day. Results： ,（1）The CT and NBNA scores of newborns were improved significantly in GM1 treatment group than routine treatment group. （2）The clinical symptom and body sign were ameliorated in GM1 treatment group than routine treatment group（P〈0.01）.（3）The concentration of NSE in middle and severity patients were more higher than normal control group, especially in the severity group（P〈0.01）.（4）The NSE＇s level of GM1 treatment and routine treatment group were reduced than before treatment, especially in the GM 1 treatment group （P〈 0.01）.Conclusion：GM1 could stabilizate nerve cell membrane, reduce cell apoptosis, reduce NSE release and exert protection effect.
出处
《中国医药导报》
CAS
2008年第9期21-23,共3页
China Medical Herald
