摘要
目的:观察蒲黄总黄酮对犬急性心肌缺血的保护作用。方法:采用麻醉开胸犬结扎左冠状动脉前降支(LAD)制备急性心肌缺血模型,观察蒲黄总黄酮对心外膜电图(EECG)、心肌梗死面积(MIS)和血清酶的影响。结果:蒲黄总黄酮可减少缺血程度(∑-ST),降低缺血范围(N-ST),缩小缺血心肌的MIS,降低血清中磷酸肌酸激酶(CPK)、乳酸脱氢酶(LDH)的活性,降低血清中游离脂肪酸(FFA)、过氧化脂质(LPO)含量,提高超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性。结论:蒲黄总黄酮对实验性心肌缺血犬的心肌具有保护作用。
Objective：The protective effects of total flavones of Pollen Typhae on acute myocardial ischemia were investigated in dogs. Methods： Acute myocardial ischemia model was made by ligation of left anterior descending artery in the anesthetized open chest dogs. The effects of total flavones of Pollen Typhae on epicardium electrocardiogram（EECG） and myocardial infarction square（MIS） were measured, and effects on enzymology in serm were also determined. Results： Total flavones of Pollen Typhae can reduce the degree and scope of myocardial ischemia （∑-ST and N-ST）, and decrease myocardial infarction square. Moreover, it also can reduce FFA and LPO content in serum, and improve SOD and GSH-Px activity in acute myocardial dogs. Conclusions： Total flavones of Pollen Typhae have the protective effects on acute myocardial ischemia dogs.
出处
《中国实验方剂学杂志》
CAS
2008年第1期39-42,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
蒲黄总黄酮
心肌缺血
心外膜电图
血清酶
total flavones of pollen typhae
myocardial ischemia
epicardium electrocardiogram
enzymology inserum
