期刊文献+

肝癌干细胞的研究现状

下载PDF
导出
摘要 传统的理论认为肿瘤的生长是所有肿瘤细胞共同增殖的结果。癌干细胞假说的提出使肿瘤越来越被设想为一种干细胞疾病[1]。这种假说认为肿瘤的生长是由一小部分肿瘤干细胞增殖的结果,这些细胞具有干细胞特性,尤其是具有自我更新、产生和维持肿瘤生长和导致细胞异质性的原始细胞及分化细胞的能力。肝癌是最常见的一种肿瘤,是否存在肝癌干细胞一直是备受关注。本文介绍有关肝癌干细胞的研究现状。
出处 《实用肝脏病杂志》 CAS 2008年第2期136-139,共4页 Journal of Practical Hepatology
  • 相关文献

参考文献27

  • 1BEACHY PA, KARHADKAR SS, BERMAN DM. Tissue repair and stem cell renewal in carcinogenesis[J]. Nature,2004,432:324-331.
  • 2COHNHEIM J. Ueber entzundung und eiterung[J]. Path Anat Physiol Klin Med, 1867,40:1-79.
  • 3PARK CH, BERGSAGEL DE, MCCULLOCH EA. Mouse myeloma tumor stem cells: a primary cell culture assay[J]. J Natl Cancer Inst, 1971,46 : 411-422.
  • 4HAMBURGER AW,SALMON SE. Primary bioassay of human tumor stem cells[J]. Science, 1977,197:461-463.
  • 5BONNET D,DICK JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J]. Nat Med, 1997,3 : 730-737.
  • 6CHIBA T, KITA K, ZHENG YW, et al. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties[J]. Hepatology, 2006,44 : 23- 26.
  • 7MA S,CHAN KW, HU L,et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells[J]. Gastroenterology, 2007,132 : 2542-2556.
  • 8YIN S,LI J, HU C, et al. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity [J]. Int J Cancer, 2007,120 : 1444-1450.
  • 9ARTERBURN LM, ZURLO J, YAGER JD, et al. A morphological study of differentiated hepatoeytes in vitro[J]. Hepatology, 1995,22 : 175-187.
  • 10BRALET MP, PICHARD V, FERRY N. DemOnstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats[J]. Hepatology,2002,36 : 623-630.

二级参考文献8

  • 1Pardal R,Clarke MF,Morrison SJ.Applying the principles of stem-cell biology to cancer.Nat Rev Cancer,2003,3:895-902.
  • 2Behbod F,Rosen JM.Will cancer stem cells provide new therapeutic targets? Carcinogenesis,2005,26:703-711.
  • 3Nakano I,Hemmati HD,Kornblum HI.Cancer stem cells in pediatric brain tumors.No Shinkei Geka,2004,32:827-834.
  • 4Thorgeirsson SS.Hepatic stem cells in liver regeneration.FASEB J,1996,10:1249-1256.
  • 5Al-Hajj M,Becker MW,Wicha M,et al.Therapeutic implications of cancer stem cells.Curr Opin Genet Dev,2004,14:43-47.
  • 6Becker R,Luthgens B,Oesch F,et al.Ha-rasVal12 but not p53Ser247 leads to a significant neoplastic transformation rate of the putative rat liver stem cells (oval cell).Carcinogenesis,1996,17:2635-2640.
  • 7Lleonart ME,Martin-Duque P,Sanchez-Prieto R,et al.Tumor heterogeneity:morphological,molecular and clinical implications.Histol Histopathol,2000,15:881-898.
  • 8邱德凯,马雄,彭延申,陈晓宇,施尧.慢性肝病患者肝脏卵圆细胞的定位和定量研究——29例慢性肝病患者肝组织病理学分析[J].中华消化杂志,2000,20(5):301-303. 被引量:15

共引文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部