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三种剂量罗库溴铵不同时间插管的效果比较 被引量:3

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摘要 目的比较三种剂量罗库溴铵不同时间插管的效果。方法选择全麻下手术ASAI-Ⅱ级患者132例,随机分为3大组6小组,每小组22例。I组给予罗库溴铵0,3mg/kg,Ⅱ组0,6mg/kg,Ⅲ组0,9mg/kg。麻醉诱导时根据分组的剂量注入罗库溴铵,每大组的单号患者给予罗库溴铵后1min行气管插管操作,双号的患者给予罗库溴铵后2min行气管插管操作。按级评定气管插管条件,并观察麻醉前、注入罗库溴铵后到气管插管前的血压、脉率和血氧饱和度,详细记录给药后有无支气管痉挛、皮疹等不良反应。结果3组患者年龄、体重、身高及术前气道评估分级等基本情况无差异。3组患者给药后未观察到支气管痉挛、皮疹等不良反应的发生。所有患者麻醉前、注入罗库溴铵到气管插管前的血压、脉率和血氧饱和度的变化差异无显著性。I组1min时仅有2例获良好级气管插管条件,12例为一般,8例不能插管,等到2-4min时才可完成插管;I组2min时有10例获优良级气管插管条件,9例为一般,3例不能插管,等到3-4min时才可完成插管;Ⅱ,Ⅲ组所有患者均获得了较满意的插管条件。结论罗库溴铵是一种快速作用的肌松药,给予0,6-0,9mg/kg剂量后,1-2min时可获得较满意的插管条件,是一种较为理想的肌肉松弛药。
出处 《广东医学》 CAS CSCD 北大核心 2008年第4期634-635,共2页 Guangdong Medical Journal
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