摘要
目的:通过检测尖锐湿疣(CA)组织中干扰素γ(IFN-γ)mRNA和白介素4(IL-4)mRNA的表达情况来研究其与尖锐湿疣复发的关系。方法:以正常包皮组织作为对照,采用原位逆转录聚合酶链反应(RT-PCR)技术检测22例治疗后复发CA患者和14例未复发患者皮损中IFN-γ mRNA和IL-4 mRNA的原位表达情况。结果:CA患者皮损局部IFN-γ mRNA和IL-4 mRNA的表达均高于正常对照组(P<0·01);复发组IL-4 mRNA的表达均高于未复发组,未复发组IFN-γ mRNA的表达均高于复发组(P<0·01)。结论:IFN-γ mRNA表达增高有利于CA的消退。
AIM： To study the expressions of interleukin 4 （IL-4） mRNA and interferon-gamma（IFN-γ） mRNA of condyloma acuminata in order to obtain a clue as to the immunological mechanisms possibly relevant for warts regression or persistence. METHODS： In situ RT-PCR was employed in surgically removed warts of 22 recurrent patients, 14 non-recurrent patients and 15 normal controls, respectively, RESULTS： The expression of IFN-γ mRNA in the non-recurrent warts was higher than in recurrent warts（ P 〈 0.01 ）; but the expression of IL-4 mRNA in the recurrent warts was higher than in non-recurrent warts （ P 〈 0.01 ）. CONCLUSION： A higher IFN-γ mRNA expression of condyIoma acuminata lesions might contribute to warts regression.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2008年第4期368-369,372,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
上海交通大学医学院科技基金资助项目(05XJ21030)
