摘要
【目的】观察中药熏蒸疗法治疗类风湿性关节炎(RA)的临床疗效及其抗炎作用机理。【方法】将22例患者随机分为熏蒸治疗组(简称熏蒸组)和非熏蒸治疗组(简称非熏组),非熏组10例给予美洛昔康和甲氨喋呤治疗,熏蒸组12例在非熏组治疗基础上加用中药熏蒸方(羌活、独活、防风、桂枝、细辛、川芎、海风藤、徐长卿、姜黄、苏木、冰片)治疗,20 d为1个疗程。观察两组治疗前后关节症状体征和血沉(ESR)、C反应蛋白(CRP)的改善情况,用酶联免疫法测定治疗前后的血清肿瘤坏死因子-α(TNF-α)和血清黏附分子(ICAM-1)的含量变化。【结果】与非熏组比较,熏蒸组能显著改善关节疼痛、压痛指数及晨僵时间(P<0.05或P<0.01)。两组治疗后均能显著性降低ESR、CRP等急性炎症指标(与治疗前比较,P<0.01),且熏蒸组在改善ESR方面优于非熏组(P<0.05)。在改善炎性细胞因子方面,两组治疗后均能显著性降低血清ICAM-1含量(P<0.05),且熏蒸组的改善作用优于非熏组(P<0.05)。【结论】中药熏蒸疗法对类风湿性关节炎有明显的抗炎作用,其抗炎机理可能与抑制炎性细胞因子ICAM-1有关。
Objective To observe the therapeutic effect of herbal fumigation and steaming for rheumatoid arthritis（RA） and to explore its anti-inflammation mechanism.Methods Twenty-two RA patients were randomized into two groups： group A（N=10） received meloxican and methotrexate,and group B（N=12） received herbal fumigation and steaming of Xunzheng Prescription（mainly composed of Rhizoma et Radix Notopterygii,Radix Angelicae Pubescentis,Radix Saposhnikoviae,Ramulus Cinnamomi,Herba Asari,Rhizoma Chuanxiong,Caulis Piperis Kadsurae,Radix Cynanchi Paniculati,Rhizoma Curcumae Longae,Lignum Sappan,Borneolum Syntheticum） additionally.The treatment lasted 20 days.The changes of joint symptoms and signs,erythrocyte sedimentation rate（ESR） and C-reactive protein（CRP） were observed before and after treatment.Serum tumornecrosis factor α（TNF-α） and intercellular adhesion molecule 1（ICAM-1） contents were detected by enzymelinked immunoassay.Results Compared with group A,joint pain and tenderness index as well as morning stiffness time were improved in group B （P〈0.05 or P〈0.01）.The inflammatory parameters of ESR and CRP were decreased in the two groups（P〈0.01 compared with those before treatment）,and the effect on ESR was better in group B than that in group A （P〈0.05）.Inflammatory factor of serum ICAM-1 was decreased in the two groups（P〈0.05 compared with those before treatment）,and the effect was better in group B than that in group A（P〈0.05）.Conclusion Herbal fumigation and steaming exerts a certain anti-inflammatory effect for rheumatoid arthritis,and its anti-inflammatory mechanism is related with the inhibition of ICAM-1.
出处
《广州中医药大学学报》
CAS
2008年第2期115-118,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局资助项目(编号:1050054)
关键词
关节炎
类风湿/中西医结合疗法
熏蒸方/治疗应用
祛风湿药/治疗应用
ARTHRITIS,RHEUMATOID/TCM-WM therapy
XUNZHENG PRESCRIPTION /therapeutic use
WIND-DAMP DISPELLING HERBS/therapeutic use
