摘要
目的评价吗啡自控静脉镇痛治疗晚期顽固性癌痛的效果及可行性。方法选择晚期顽固性癌痛患者22例,应用PCIA方法治疗,观察疼痛程度(PI)及疼痛缓解程度(PAR),并记录疼痛开始缓解的时间、持续缓解的治疗时间。结果吗啡PCIA给药前后疼痛评分分别为8.45±1.057和2.95±2.42(P<0.05);疼痛缓解程度:完全缓解率18.2%,明显缓解率36.4%,中度缓解率31.8%;吗啡PCIA治疗时间平均达1.15个月,疼痛开始明显缓解时间平均为1.12 h。结论晚期顽固性癌痛治疗中吗啡PCIA给药效果满意,且简单、易行,提高了癌痛患者的生活质量,可作为口服、肌注吗啡或外用芬太尼镇痛无效时的二线治疗手段。
Objective To investigate efficasy and feasibility of morphine patient-controlled intrave- nous analgesia （PCIA） with morphine in treatment of the patients with advanced refractory cancer pain. Methods Twenty-troo patients with advanced refractory cancer pain were selected. The morphine PCIA method was used to observe pain intensity （PI） and the degree of pain relief （PAR）, and record the time of beginning and duration of pain relief. Results The pain scores before and after the use of morphine PCIA were 8.45 ＋ 1. 057 and 2. 95 ＋ 2. 42 respectively （ P 〈 0. 05 ）. The degree of pain relief were as follows ： complete remission rate was 18.2%, significant remission rate 36. 4%, moderate remission rate 31.8%. The average duration of morphine PCIA treatment was 1.15 months, and the average time of beginning of significant pain relief was 1.12 hours, Conclusion In the treatment of advanced refractory cancer pain, morphine PCLA not only can give obvious results, and is simple, easy, improves the quality of life in cancer patients, but also can be used as second-line treatment when oral, intramuscular injection of morphine or topical analgesia with fentanyl is ineffective.
出处
《中国肿瘤临床与康复》
2008年第2期191-192,F0003,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
晚期顽固性癌痛
吗啡
PCIA
Advanced refractory cancer pain
Morphine
PCIA
