摘要
目的:探讨甲状腺自身抗体与甲状腺相关性眼病(Thyroid-associated ophthalmopathy,TAO)、甲状腺机能亢进症突眼(甲亢突眼)及甲状腺机能亢进(甲亢)的关系。方法:甲状腺相关性眼病35例,甲亢突眼37例,甲亢83例,正常对照90例,分别检测其甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)、促甲状腺受体抗体(TRAb)。结果:四组的TGA阳性数(率)分别为3(8.6%)、6(16.2%)、16(19.3%)、6(6.7%),TMA阳性数(率)分别为6(17.2%)、7(18.9%)、32(38.6%)、12(13.3%),TGA、TMA双阳性数(率)分别为1(2.6%)、4(10.8%)、11(13.8%)、0(0.0%),TRAb阳性数(率)分别为22(62.9%)、31(83.8%)、70(84.3%)、6(6.7%)。结论:TGA、TMA与TAO的相关性不大,诊断意义很小,TRAb与TAO有较好的相关性,对其早期诊断、治疗和随访有很大价值。
Objective：To assess the relation between the thyroid autoantibodies and thyroid-associated ophthalmopathy（TAO）,Hyperthyroid Graves＇ disease（GD） and Hyperthyroidism.Methods：35 patients with TAO,37 with GD,83 with Hyperthyroidism and 90 normal persons underwent evaluation of thyroid abnormalities by means of thyroglobulin antibody（TGA）,thyroid microsoraal antibody（TMA）,TSH receptor antibodies（TRAb）.Results：The positive numbers（rates） of TGA were 3（8.6%）,6（16.2%）,16（19.3%）,6（6.7%）for TAO,GD,Hyperthyroidism and normal.The positive numbers（rates） of TMA were 6（17.2%）,7（18.9%）,32（38.6%）,12（13.3%）.TGA and TMA were 1（2.6%）,4（10.8%）,11（13.8%）,0（0.0%）.The positive numbers（rates） of TRAb were 22（62.9%）,31（83.8%）,70（84.3%）,6（6.7%）.Conclusion：TGA,TMA are less reliable and do not seem to play an important role with regard to the diagnosis of TAO.TRAb has high relation with TAO and seem to play an important role in early diagnosis,therapy and follow-up studies.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2008年第4期371-373,共3页
Chinese Journal of Immunology
关键词
甲状腺相关性眼病
甲亢突眼
甲状腺机能亢进
甲状腺自身抗体
Thyroid-associated ophthalmopathy（TAO）
Hyperthyroid Graves＇disease（GD）
Hyperthyroidism
Thyroid autoantibodies
