摘要
目的:研制一种新型的恩诺沙星纳米粒制剂。方法:以聚乳酸为载体材料,采用溶剂挥发法制备了恩诺沙星聚乳酸纳米粒,对其形态学、载药量、包封率以及粒径分布等性质进行了研究,并对其进行相关的质量评价。结果:制备的恩诺沙星聚乳酸纳米粒的包封率平均为71.0%,载药量平均为11.3%,平均粒径为66.8 nm,粒径范围为30.0 nm^117.5 nm,电子透射显微镜下观察纳米粒,基本呈较光滑圆整的球形,大小较均匀,且粒径分布较窄。结论:制备工艺可行且制备的恩诺沙星聚乳酸纳米粒包封率相对较高,质量稳定,重现性好。
Objective： To study and develop the novel preparation of enrofloxaein nanoparticles, Methods： The nanoparticles were prepared hy solvent evaporation method with polylactic acid as vehicle material. The morphology of the nanoparticles, the drug loading, the entrapment efficiency and the panicle size distribution were studied. The correlative quality was assessed, Results： The result of electron micrography and the size distribution showed that the nanoparticles were small spherical, The mean diameter of nanoparticles were 66.8 nm, with the range of 30 nm-117.5 nm, about 71.0% of enrofloxacin content were entrapped into the enrofloxacin nanoparticles, and the average drug loading is 11.3%, Conclusion： The enrofloxacin was highly entrapped into nanopanicles with good reprnducibility and stability,
出处
《河南大学学报（医学版）》
CAS
2008年第1期28-30,共3页
Journal of Henan University:Medical Science
