摘要
实验发现，在亚硫酸钠存在下，高锰酸钾与舒必利能够发生反应，并产生较强的化学发光。据此采用流动注射技术，建立了利用高锰酸钾-亚硫酸钠-舒必利体系测定舒必利的化学发光分析法。方法线性范围为1．0×10^-7～1．0×10^-5g／mL；检出限为3．0×10^-8g／mL；对1．0×10^-6g／mL舒必利测定的相对标准偏差为1．59／5（n=11）；本法已用于片剂中舒必利含量的测定，结果与药典方法测定值一致。
Chemiluminescence reaction of sulpiride with potassium permanganate in the presence of sodium sulfite as an enhancer was investigated. A new chemiluminescence method for the determination of sulpiride with flow injection technique was developed. The detection limit was 3 × 10^-8 g/mL, the relative standard deviation was 1.5% （1.0× 10^-6 g/mL sulpiride, n=11）, and the linear range was 1.0 × 10^-7-1.0× 10^-5 g/mL. The method has been applied to the determination of sulpiride in the tablets and the results were consistent with the method in the Chinese pharmacopoeia.
出处
《分析科学学报》
CAS
CSCD
2008年第2期243-245,共3页
Journal of Analytical Science
关键词
化学发光分析
高锰酸钾
舒必利
亚硫酸钠
Chemiluminescence analysis
Potassium permanganate
Sulpiride
Sodium sulfite
