摘要
目的:评价三维适形放疗(3DCRT)对未行手术切除小肝癌的治疗疗效。方法:2000年1月至2005年12月期间,对28例无法进行手术切除,或患者拒绝手术的原发性小肝癌进行3DCRT。可见肿瘤体积(GTV)为58.47±26.46cm3(13.85cm3-95.36cm3),每次分割剂量2Gy-6Gy,照射次数为6-35次(11±3次),肿瘤剂量53.6±6.6Gy,每周3-5次。结果:CR16例(59%),PR10例(37%),SD0例,PD1例(3.7%)。1、2和3年生存率分别为100%、85%和60%。结论:3DCRT是原发性小肝癌有效的治疗手段,毒副反应较小。
Objective：To evaluate the therapeutic effect of three- dimensional conformal radiotherapy （ 3 DCRT） on unresectable small primary liver cancer （PLC）. Methods： From January 2000 to December 2005, 28 patients with unresectable small PLC or unwillingly undergo operation were treated with 3DCRT. The mean value of GTV was 58.47 ±26.46cm^3 （ 13.85 - 95.36 cm^3 ）. Radiotherapy was performed at an exposure of 2 - 6 Gy/time, 3 - 5 times/ week, 53.6 ± 6.6Gy and 6 - 35 （ 11 ± 3 ） times. Results： Follow - up of all patients showed a complete response （CR） in 16 of 28 patients （57%） , a partial response （PR） in 11 patients （39%） , no patient showed stable disease （SD） and 1 patient showed progressive disease （PD）（4% ）. The overall survival rates at 1, 2, and 3 years were 100% , 85%, and 60% , respectively. Condusion：3DCRT is an effective and feasible approach to treat patients with small PLC.
出处
《现代肿瘤医学》
CAS
2008年第5期793-795,共3页
Journal of Modern Oncology
基金
广西医疗卫生重点科研课题(重200532)
广西自然科学基金资助项目(桂科自:0728198)
关键词
原发性小肝癌
三维适形放射治疗
疗效
small primary liver cancer
three-dimensional conformal radiotherapy
effect
