摘要
目的应用拉莫三嗪联合治疗3～14岁的难治性癫痫儿童35例。方法对于全身性发作,无论原发性或是继发性,联合应用拉莫三嗪能有效控制癫痫发作。结果拉莫三嗪尤其适用治疗复杂部分性发作等伴有精神障碍的难治性癫痫,疗效确切。结论多药联合治疗Lennox综合征时应首选拉莫三嗪。拉莫三嗪的毒副反应小,但皮疹是其常见且较为严重的副作用。拉莫三嗪与卡马西平等酶诱导剂合用时可适当加大剂量;临床应用拉莫三嗪时应考虑本国人群的特质,并加强拉莫三嗪血药浓度的监测。
Objective To study the clinical effects of treating refractory epilepsy with lamotrigine in 35 children of 3-14 years old . Methods Lamotrigine was used to treat generalized seizures of primary or secondary refractory epilepsy . Results The therapeutic effects were satisfactory , esp. in refractory epilepsy with complex partial seizures combined with dysphrenia. Conclusions Lamotrigine is the first choice in treating Lennox syndrome with therapeutic alliance. Lamotrigine has less side effects with erythra being the main and most . When combined with Carbamazepine , the dose could be moderately increased . Chinese body constitution should be considered and drug concentration needs to be monitored in its clinical use .
出处
《浙江临床医学》
2008年第4期453-454,共2页
Zhejiang Clinical Medical Journal
关键词
拉莫三嗪
临床
癫痫
Lamotrigine
Clinical
Epilepsy
