摘要
在微波辐射和对甲基苯磺酸的催化作用下,5-芳基-1,3-环己二酮与邻氨基苯甲腈进行缩合反应,得到了N-取代的2-氨基苯甲腈衍生物,在K2CO3和Cu2Cl2的催化作用下进一步合环,得到3-芳基-9-氨基-1,2,3,4-四氢吖啶-1-酮衍生物,用LiAlH4还原羰基得到3-芳基-9-氨基-1,2,3,4-四氢吖啶-1-醇衍生物.新合成化合物的结构均经元素分析、红外光谱和核磁共振光谱予以确认.
Under microwave irradiation and using p-toluenesulfonic acid as a catalyst, the condensation reaction of 5-aryl-1,3-cyclohexanediones with o-anthranilonitrile afforded the corresponding N-substituted-2- aminobenzonitriles, which were followed by the intramolecular cyclization in the presence of potassium carbonate and cuprous chloride to give 3-aryl-9-amino-1,2,3,4-tetrahydroacridin-l-one. Then reduction of these acridinone compounds with lithium aluminum hydride in the ethyl ether afforded 3-aryl-9- amino- 1,2,3,4-tetrahydroacridin- 1-ol derivatives. The structures of all these new compounds were characterized by elemental analysis, IR and IH NMR and ^13C NMR spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第4期750-754,共5页
Chinese Journal of Organic Chemistry
基金
江苏省教育厅自然科学基金(No.05KJB350031)资助项目.
