摘要
目的了解甲泼尼龙治疗支气管哮喘急性发作的临床效果。方法将支气管哮喘患者93例随机分为两组,实验组48例,对照组45例;对照组常规静点二羟丙茶碱、吸入β2受体激动剂、输液等治疗,实验组在相同对照组治疗基础上,加用甲强龙80mg/次,2次/d静点。治疗前和治疗第2天、第4天分别观察症状、体征及动脉血PaO2变化。结果治疗前两组患者均为支气管哮喘急性发作,动脉血PaO2平均值比较差异无统计学意义;治疗第2天、第4天,治疗组缓解率分别为79.17%、95.83%,对照组缓解率分别为62.22%、77.78%,两组比较差异有统计学意义;治疗第2天、第4天实验组动脉血PaO2值分别为(79.1±7.4)mmHg、(93.4±4.7)mmHg,对照组动脉血PaO2值分别为(69.5±6.8)mmHg、(87.6±4.3)mmHg,两组比较差异有统计学意义。结论甲泼尼龙治疗支气管哮喘急性发作有效且快速,可快速缓解哮喘症状、缩短住院日期。
Objective To study the treatment of acute attack of bronchial asthma with methylp-radnisolone, Methods The control group was given conventional therapy such as diprophylline, β2 receptor agonist, transfusion, vein-inputtlng, inhalansing oxygen etc. Besides conventional therapy for the control group, the experiment group was given methylprednisolone 80 mg/time, 2 tlmes/day, The symptoms and signs, the arterial blood gas were recorded before the treatment and on the 2nd and 4th day after the treatment and the data were analyzed. 93 inpatients with bronchial asthma were divided into two groups. The experiment group had 48 patients and control group had 45 patients. Result Before the treatment, all patients of the two group had acute attack of bronchial asthma. The means PaO2 of the two groups were compared and the differences were not significant. The rates of perfect effectiveness were 79. 17% and 95.83%, respectively, in the 2nd and 4th day for the experiment group and 62, 22% and 77.78% in the control group：P 〈0. 05 in each of the group comparisons. Measures of PaO2 in the experiment group on the 2nd and on the 4th day after the treatment were respectively 62. 22% （28/ 45 ） and 77.78% （35/45） mm Hg and in the control group the respective figures were （69. 5 ± 6. 8 ） mmHg and （87. 6 ± 4. 3 ） mmHg： P 〈 0. 05 in the group comparisons. Conclusion blethylp-rednisolone is quick and effective in the treatment of acute attack of bronchial asthma, which may relieve asthma symptom and shorten the length of hespital stay.
出处
《临床肺科杂志》
2008年第5期597-598,共2页
Journal of Clinical Pulmonary Medicine
