摘要
目的探讨促动力药多潘立酮(吗丁啉)和胆盐结合药铝碳酸镁对胆汁反流性胃炎的疗效及胃内24h胆汁的影响。方法25例胆汁反流性胃炎患者,经胃内24h胆汁监测证实,记录上腹痛、饱胀、恶心、呕吐症状的积分后,予以口服吗丁啉10mg,每日餐前15min服用,3次/d,铝碳酸镁0.5g,每日餐后60min服用,3次/d。治疗4周后观察上述症状积分的变化,并复查胃内24h时胆汁反流情况。结果治疗2周后4种症状积分较治疗前显著降低(P<0.05)。4周后腹痛、饱胀症状进一步改善,24h胃内胆汁反流总时间百分比由治疗前的(30.4±20.2)%降至(15.6±6.6)%(P<0.01),反流次数由治疗前的(104.9±57.6)次降至19.6次。结论吗丁啉与铝碳酸镁合用能有效缓解胆汁反流性胃炎的症状,降低胃内胆汁反流指标,是治疗胆汁反流性胃炎的有效方案。
Objective To evaluate the effect of prokinetics domperidone combined with hydrotaleid on bile reflux gastritis and 24 hour intragastrie bile concentration. Methods Twenty five eases of bile reflux gastritis were confirmed by 24 hours bile monitoring. The severity of the symptoms including abdominal pain, distention, nausea and vomiting was recorded and evaluated. Bile was investigated before and after 2 and 4 weeks treatment with domperidone 10 mg three times a day combined with hydrotaleid 0.5 g three times a day. Intragastrie 24 hours bile monitoring was also reexamined after 4 weeks treatment. Results The severity of all the four symptoms significantly decreased after 2 weeks treatment （ P 〈 0. 05）. The severity of abdominal pain and distention further decreased after 4 weeks treatment （ P 〈 0.01 ）. The total fraction time of bile decreased from （30.4±20.2）% to （15.6±6.6）% （ P 〈0.01） and the number of bile reflux decreased from （104.9±57.6） to （50.8±19.6） （ P 〈 0.01 ）. Conclusion Domperidone combined with hydrotaleid can relieve the symptoms of bile reflux gastritis and decreased the index of 24 h intragastrie bile monitering. Domperidone combined with hydrotalcid is an effective treatment program for bile reflux gastritis.
出处
《临床和实验医学杂志》
2008年第4期67-68,共2页
Journal of Clinical and Experimental Medicine
