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辛伐他汀治疗慢性心力衰竭的效果观察

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摘要 目的观察辛伐他汀对慢性心力衰竭(CHF)患者心功能的影响。方法选择CHF患者60例,随机分为治疗组30例、对照组30例,入院当日所有患者给予常规治疗,1周后治疗组给予辛伐他汀10mg/d,疗程为6个月。观察治疗前后所有患者的临床症状、心功能分级、超声心动图、高敏C反应蛋白(HS-CRP)与生化指标的变化及不良反应。结果治疗组NYHA分级改善、左室内径缩小,左室射血分数增加,HS-CRP下降(P<0.05或0.01);对照组NYHA分级改善、左室射血分数改善(P<0.05),治疗后治疗组与对照组比较LVEF增加更明显(P<0.01);治疗后治疗组总胆固醇、低密度脂蛋白胆固醇降低(P<0.05);无过敏反应。结论CHF患者在常规抗心力衰竭药物治疗基础上,加用辛伐他汀,可进一步改善患者的心功能、降低CRP,无明显不良反应。
作者 赖敏
机构地区 广西钦州市第一人民医院心内科
出处 《右江民族医学院学报》 2008年第2期205-206,共2页 Journal of Youjiang Medical University for Nationalities
关键词 心力衰竭 充血性 心脏功能 辛伐他汀
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献5

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二级参考文献15

  • 1Sola S, Mir MQ, Rajagopalan S, et al. Statin therapy is associated with improved cardiovascular outcomes and levels of inflammatory markers in patients with heart failure. J Card Fail, 2005,11 (8) : 607-612.
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共引文献26

右江民族医学院学报
2008年 第2期

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