摘要
肌萎缩性侧索硬化症(ALS)是运动神经元选择性死亡而导致运动功能障碍的神经性疾病,是成年人运动神经元病中最常见的疾病。已有很多学说讨论其发病机制,并且建立了ALS动物模型。随着现代生物学的发展和不同学科间的相互渗入,各种治疗策略在ALS模型实验中得到实践并有望用于临床。简要综述了ALS治疗方法在转基因动物模型中的研究进展。
The most common motor neuron disease in human adults is amyotrophic lateral sclerosis（ALS）. The primary hallmark of ALS is the selective killing of motor neurons, which initiates a progressive paralysis in mid-life. The mechanism underlying the characteristic selective degeneration and death of motor neurons in this common adult motor neuron disease has remained a mystery, and there are some animal models of ALS. With the development of modem biology and the mutual infiltration of different disciplines, various strategies in the treatment of ALS model were applied in practice and are expected to be used for clinical.
出处
《生物技术通讯》
CAS
2008年第2期310-312,共3页
Letters in Biotechnology
