摘要
目的研究脑梗死后癫患者血清细胞因子水平的改变。方法应用放射免疫法检测87例脑梗死后癫患者(脑梗死癫组)和75名健康体检者(正常对照组)的血清肿瘤坏死因子α(TNF-α),白细胞介素(IL)-2和IL-6水平。结果脑梗死癫疒间组血清TNF-α[(2.5±0.57)ng/L]、IL-2[(9.0±0.83)ng/L]及IL-6[(97.5±13.1)ng/L]水平明显高于正常对照组[TNF-α(0.89±0.36)ng/L,IL-2(4.3±1.5)ng/L,IL-6(13.3±11.1)ng/L](均P<0.01)。结论脑梗死后癫患者的血清细胞因子TNF-α、IL-2及IL-6水平显著升高,提示细胞因子可能在脑梗死后癫的发病中起重要作用。
Objective To study the change of the level of serum cytokines in patients with epilepsy after cerebral infarction. Methods The levels of serum interleukin （IL） -2, IL-6 and tumor necrosis factor-α （TNF-α） in 87 patients with epilepsy after cerebral infarction（epilepsy group ） and 75 normal controls （NC group） were measured by radioimmunoassay. Results The levels of TNF-α[ （2.5 ±0.57） ng/L], IL-2[ （9.0 ±0. 83） ng/L] and IL-6 [ （97.5 ± 13.1 ）ng/L] in epilepsy group were significantly higher than those in the NC group [ TNF-α （0.89 ± 0. 36） ng/L, IL-2 （4.3±1.5）ng/L, IL-6（13.3±11.1）ng/L]（allP〈0.01）. Conclusion The serum cytokines TNF-α, IL-2 and IL-6 levels in patients with epilepsy after cerebral infarction are significantly higher, which indicated that cytokines may play an important role in the pathogenesis of epilepsy after cerebral infarction.
出处
《临床神经病学杂志》
CAS
北大核心
2008年第2期103-104,共2页
Journal of Clinical Neurology
关键词
脑梗死
癫痫
细胞因子
cerebral infarction
epilepsy
cytokine
