摘要
目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)和胰岛素抵抗(IR)的关系。方法分析对照组、肥胖的轻度OSAS组、肥胖的中重度OSAS组、非肥胖的轻度OSAS组、非肥胖的中重度OSAS组的体重指数、HOMA2-IR等。结果①肥胖的轻度、中重度OSAS组和非肥胖的中重度OSAS组的HOMA2-IR高于对照组(P(0.01)。肥胖的中重度OS-AS组的HOMA2-IR高于肥胖的轻度OSAS组(P(0.01),非肥胖的中重度OSAS组的HOMA2-IR高于非肥胖的轻度OSAS组(P(0.05)。②HOMA2-IR与AH I和BM I呈显著正相关(r分别为0.427、0.546,P(0.01),AH I与BM I呈显著正相关(r为0.428,P(0.01)。③多元逐步回归分析,得出影响HOMA2-IR的因素依次是BM I和AH I。结论OSAS和IR存在独立的相关性,且随着OSAS程度的增加IR亦加重。
Objective To explore the relationship of obstructive sleep apnea syndrome and insulin resistance. Methods Depending on the apnea hypopnea index （AHI） and body mass index （BMI）all cases were divided into control group（ n = 22 ）, mild OSAS with obesity group （n = 17）, moderate -severe OSAS with obesity group（ n = 24）, mild OSAS without obesity group （ n = 15） and moderate - severe OSAS without obesity group （ n = 22 ）. HOMA2 - IR, BMI, triglyceride （ TG）, total cholesterol （ TC）, high - density lipoprotein - cholesterol （ HDL - C） and low - density lipoprotein - cholesterol （ LDL - C ） were measured and analyzed. Results （1）HOMA2 -IR in mild, moderate -severe OSAS with obesity group and moderate -severe OSAS without obesity group were significantly higher than that of control group（ P 〈 0.01 ）. HOMA2 - IR in moderate - severe OSAS with obesity group was significantly higher than in mild OSAS with obesity group（ P 〈 0.01 ）. HOMA2 - IR in moderate - severe OSAS without obesity group was significantly higher than in mild OSAS without obesity group（ P 〈 0.05）. （2）HOMA2 - IR was positively correlated with AHI（ r =0.427, P 〈 0. 01） and BMI（ r =0.546, P 〈 0.01）, AHI was positively correlated with BMI （ r =0. 428 , P 〈 0. 001 ）. （3）The results of multivariate stepwise regression analysis indicated that AHI was an independent risk factor for the HOMA2 - IR index beside BMI. Conclusion There wiss an independent correlation between OSAS and IR. IR correlate significantly with the severity of OSAS.
出处
《临床医学》
CAS
2008年第3期7-9,共3页
Clinical Medicine
基金
温州市科技局基金项目(Y20060132)
