摘要
目的评价初诊Ⅱ型糖尿病患者使用双相门冬胰岛素70/30(BIAsp30)每天3次餐前注射强化降血糖的疗效。方法比较使用BIAsp30每天3次餐前注射和使用门冬胰岛素(AspaR)每天3次餐前注射及诺和灵N睡前1次注射(每天4次注射)强化降血糖治疗4周,观察临床糖化血红蛋白(GHbAlc)达标率、胰岛素分泌功能的变化和血脂代谢变化。结果使用BIAsp30每天3次餐前注射组糖化血红蛋白(GHbAlc)的达标率是77.2%,每天4次注射组,达标率是75.1%,两种方法均可以使胰岛B功能有所恢复,第一种方法的空腹c-肽和胰岛素的分泌分别提高18.2%和20.1%,与第二种方法相仿,治疗前后比较有统计学意义(p<0.05);总胆固醇和甘油三脂分别下降17.14%和25.37%,治疗前后比较有统计学意义(p<0.05)。结论初诊T2DM患者使用BIAsp30每天3次注射可以达到强化降血糖的作用,同时可以改善胰岛β细胞分泌功能,间接改善血脂紊乱,是一种简便、有效的强化降血糖方法。
Objective To evaluate the clinic effect about using Insulin BIAsp 30 intensive treatment in newly diagnosed type 2 diabetic patients before dinings 3 time a day. Methods To use two methods （3 times a day of Insulin BIAsp 30 and 3 times of Insulin Aspart ＋1 time of Novolin N） to intensively treat the newly type 2 diabetes for 4 weeks, and to compare the treatment effect about GHbAlc, pancreatic function, cholesterel and triglyceride. Results The rate of wishing standard about GHbAlc in two methods is 77% and 75%, C-peptide and Insulin made increase about 18.2% and 20.1%, cholesterol and triglyceride made decrease about 17.14% and 25.34%. It all had statistics signification （p〈0.05）. Conclusion It is a good method to use Insulin BIAsp 30 to intensively treat newly diagnosed type 2 diabetic patients, it not only can improve the pancreatic B-cell funct ion but also can decrease the disorder of hyperlipidemia.
出处
《海南医学》
CAS
2008年第5期54-55,57,共3页
Hainan Medical Journal
