摘要
学术背景:红外光谱技术在疾病诊断和病理分析方面具有潜在的重要应用价值,并可为治疗提供准确的参考信息。目的:分析冠状动脉粥样硬化性心脏病(简称冠心病)患者内关穴红外辐射光谱中的特异性病理信息。设计:病例-对照观察。单位:上海中医药大学附属龙华医院。对象:检测于2003-04/2005-04进行,其中50例冠心病患者来自龙华医院心内科门诊,男21例,女29例;平均年龄58.1岁;非47例冠心病正常人由广告招募,男25例,女22例;平均年龄50.6岁。受试者均自愿参加检测。方法:采用中国科学院上海技术物理研究所制造的高灵敏度PHE201体表红外光谱仪,对50例冠心病患者内关穴作红外辐射光谱检测,并以47例健康成年人为对照进行比较分析。检测内关穴1.5～16μm波长范围内的红外辐射光谱,扫描间隔为0.2μm,共检测73个波长。主要观察指标:冠心病患者和正常人内关穴不同波长处的红外辐射强度。结果:在检测的73个波长中,左内关穴23个、右内关穴32个波长处的红外辐射强度,冠心病患者与正常人间存在显著差异(P<0.05～0.001)。其中与能量代谢有关的2.0～2.5μm波长处的红外辐射强度冠心病患者明显低于正常人(P<0.05～0.005)。冠心病患者两侧内关穴红外辐射强度有显著差异的波长数明显多于正常人(P<0.001)。结论:①冠心病患者内关穴红外辐射光谱中存在特异性病理信息。②冠心病患者内关穴区的能量代谢和气血功能活动低下。
BACKGROUND： Infrared spectrum technology has potential and important value of application in diagnosing disease and analyzing pathology, as well as providing references for proper treatment. OBJECTIVE： To analyze the distinctive pathological information in the spectrums of infrared radiation at Neiguan （PC 6） acupoint of patients with coronary athernsclerntic heart disease （CAHD）. DESIGN： Case-control study. SETrING： Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. PARTICIPANTS： The study was conducted from April 2003 to April 2005 in patients with CAHD from Out-Patient Clinic in Longhua Hospital （21 males and 29 females, averagely 58.1 years）. Forty-seven healthy volunteers were all from advertisement （25 males and 22 females, averagely 50.6 years）. All the subjects were voluntary. METHODS： PHE201, a high-sensitive infrared spectrum detective device （Shanghai Institute of Technical Physics of Chinese Academy of Sciences, China） was applied to detect the spectrums of infrared radiation at Neiguan in 50 patients with CAHD and 47 healthy adults were selected as control for comparison. The scanning range was from 1.5 μm to 16 μm, 73 detected wavelength spots were scanned at Neiguan of all the subjects, and the scanning spacing was 0.2 μm. MAIN OUTCOME MEASURES： Intensity of infrared radiation at Neiguan between CAHD patients and normal controls at different wavelengths. RESULTS： The intensities of infrared radiation of CAHD patients were significantly different from that of the healthy volunteers at 32 spots of the fight Neiguan as well as at 23 spots of the left Neiguan among the 73 detected wavelength spots （P 〈 0.05-0.001）. At 2-2.5 μm wavelength spots that were related to the energy metabolism, the intensities of infrared radiation of CAHD patients were significantly lower than the healthy volunteers （P 〈 0.05-0.005）. Concerning the difference in intensities of infrared radiation between the left and the fight Neiguan, the CAHD patients had more wavelength spots than healthy volunteers did （P 〈 0.001）. CONCLUSION： （1）Distinctive pathological information exists in the infrared spectrums at Neiguan in CAHD patients. （2）CAHD patients have hypo-activities of energy metabolism and hypo-function of qi and blood in the area of Neiguan.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第13期2583-2586,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金资助项目(30572306)
国家“九七三”课题(2005CB523306)
上海市科技发展基金科技攻关项目(07DZ19722-2)~~
