摘要
目的:探讨骨碱性磷酸酶(以下简称BALP)在维生素D缺乏性佝偻病诊断及疗效评估中的价值。方法:应用酶联免疫法原理测定治疗组末梢血BALP,同时摄双腕X线照片,对照组测定血钙(Ca)、磷(P)、碱性磷酸酶(ALP),将两组阳性率进行比较。结果:治疗组BALP异常值检出率(≥200U/L)占52.9%,远高于对照组Ca、P、ALP异常值检出率,经统计学处理差异有显著性。在267例BALP>250U/L(阳性结果)中,有佝偻病临床表现246例(92.1%),符合佝偻病X线表现238例(89.1%)。在BALP>250U/L组中符合佝偻病诊断的比BALP200～250U/L组高,经统计学处理差异有显著性。结论:BALP对佝偻病的检测比Ca、P、ALP要敏感,以BALP>250U/L作为诊断佝偻病标准与佝偻病临床表现和腕关节X线照片有较高的符合率。对BALP检出异常值(≥200U/L)建议早期干预和治疗,1～3个月治疗后复查BALP作为疗效评估在临床收到较好效果,值得推广。
Objective： To study the value of bone alkaline phosphatase （BALP） during diagnosis and curative effect evaluation of vitamin D deficient rickets. Methods： Use enzyme-linked immunosorbent assay to measure ending blood BALP of the treated group, and do dual wrist X-Ray at the same time. Blood Ca, P, ALP in the control group were also measured. The positive rate of both groups was compared. Results： For the treated group, the abnormality detection rate of BALP（≥200 U/L） was 52. 9%, much higher than that of Ca,P and ALP of the control group. The significant difference was found. Among 267 samples of BALP〉250U/L（positive result）, 246 had clinical presence of rickets （92. 1% ）, and 238 had the X-Ray result that was complied with rickets （89.1%）. In the group of BALP〉 250U/L, the percentage of having rickets was higher than that of BALP200-250U/L, and was considered as significant difference after statistic analysis. Conclusion： BALP is more sensitive than Ca,P,ALP in detection of rickets. Using BALP〉250U/L as the diagnosis standard of rickets has a high compliance rate with clinical presence and wrist X-Ray. It＇s suggested that early treatment should be carried out when BALP was abnormality （≥200 U/L）. And after treatment of 1 to 3 months, checking BALP again as the curative effect evaluation standard is a good method, and worth to be popularized.
出处
《华夏医学》
CAS
2008年第1期45-47,共3页
Acta Medicinae Sinica
基金
广西科学基金资助项目(桂科基0448081)
