摘要
给予小鼠灌胃染毒亚砷酸钠,观察急性及亚慢性染毒后小鼠全血及组织中谷胱甘肽(GSH)水平。结果表明:在急性实验中,全血及肾脏中GSH含量逐渐增加.且呈剂量-效应关系;肝脏及心脏中GSH含量于低剂量显著增加,高剂量则显著下降;亚慢性实验中,高砷组全血GSH含量显著增加,超砷组则显著降低;肝中GSH含量从低砷组即开始降低;肾脏GSH含量仅在高砷组才开始显著降低;心脏GSH含量随染毒剂量增加而逐渐降低,并呈明显剂量-效应关系。提示不同剂量、不同时间染毒引起血液及组织中GSH含量的变化不同。
To investigate the influence of arsenic on GSH content, the level of GSH in blood and tissues of mice were detected in acute and subchronic experiment. The result showed that in acute experiment, GSH content in blood and kidney increased gradually in a dose-effect manner and the GSH level in liver and heart increased significantly during the low-dose, decreased significantly during the high-dose. In subchronic experiment, the level of blood GSH increased in high-arsenic group and decreased in ultra-arsenic group sigificantly; GSH level in liver began to reduce from low-arsenic group;only in high-arsenic group did the decrease of GSH level in kidney begin; the GSH level of heart also decreased gradually in a dose-effect manner. It is suggested the variations of GSH content in blood and tissues caused by arsenic were different.
