摘要
目的：观察脑出血是否能引起心电图（ＥＣＧ）异常。方法：５６只Ｗｉｓｔａｒ大鼠随机分为３组：对照组１０只，左侧内囊血肿组２２只，右侧内囊血肿组２４只。麻醉后，用监护仪监测动物的ＥＣＧ，将１２０μｌ新鲜鼠血注入大鼠内囊处，观察其ＥＣＧ变化。结果：右侧内囊血肿组的ＥＣＧ异常发生率为６２．５％（１５／２４），左侧内囊血肿组为３６．４％（８／２２），２组无统计学差异（χ２＝３．００５７，Ｐ＞０．０５）。ＥＣＧ异常表现为ＳＴ段上抬（２４／４６）、心房扑动（１２／４６）和频发室性早搏（７／４６）。７０．８％鼠（１７／２４）的ＥＣＧ异常发生在内囊血肿形成后３小时内。对照组在监测过程中未发现ＥＣＧ异常。结论：内囊血肿可引起ＥＣＧ异常。
Objective:To observe whether electrocardiographic (ECG) abnormality can be induced by cerebral hemorrhage.Methods:Fiftysix Wistar rats were divided into 3 groups:controls group ( n =10),left internal capsule hematoma group ( n =22) and right internal capsule hematoma group ( n =24).Following anesthesia,120 μl fresh blood was injected into internal capsule of rats and ECG changes were observed.Results:Frequency of ECG abnormality was 62 5% (15/24) in the right internal capsule hematoma group,and 36 4% (8/22) in the left internal capsule hematoma group,respectively.There was no significant difference between 2 groups (χ 2= 3 005 7 , P >0 05).The ECG abnormality was characterized by ST segment elevation (24/46),atrial flutter (12/46),and highfrequency ventricular premature beats(7/46).ECG abnormality in 70 8% 17/24 rats occurred within 3 hours of intracerebral hematoma formation.The ECG abnormality was not found in the control group during the observation period.Conclusions:ECG abnormality can be induced by cerebral hemorrhage.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第11期648-649,共2页
Chinese Critical Care Medicine
关键词
内囊血肿
动物模型
心电图
脑出血
internal capsule hematoma
animal model
electrocardiography
