摘要
目的观察CD68在胆囊壁中的表达和分布,探讨其与胆囊壁的脂质转运、胆固醇结石发病之间的关系。方法PV-9000免疫组化方法检测CD68在34例胆固醇结石病人、19例非胆囊结石病人及15例对照组胆囊壁标本中的表达。结果CD68表达主要分布在胆囊粘膜上皮细胞顶侧,胆固醇结石病人、非胆囊结石病人胆囊壁CD68的表达显著高于对照组,其差异有统计学意义(P<0.05)。结论胆囊壁中CD68在胆囊胆固醇结石病人和非胆囊结石病人的表达上调,反映了胆囊壁对脂质的吸收和转运功能,与胆固醇结石的形成密切相关。
Objective To observe the expression and distribution of CD68 in gallbladder wall and investigate their relationship with the lipid transport of gallbladder wall and cholesterol gallstone. Methods The specimens of 34 patients with cholesterol gallstone ,19 patients without gallstone and 15 controls were studied by PV-9000 immunohistochemical method to detect the CD68 protein expres- sion. Results CD68 was expressed in the apical domain of gallbladder epithelial ceils. The expression of CD68 in patients with cho｜es- terol gallstone and without gallstone was signigicantly higher compared with that in control group（P 〈 0. 05 ）. Conclusion The expres- sion of CD68 protein is increased in patients with cholesterol gallstone and without gallstone, indicating that CD68 was related with the lipid absorption and transportation of gallbladder wall and the formation of cholesterol gallstone.
出处
《肝胆外科杂志》
2008年第2期141-143,共3页
Journal of Hepatobiliary Surgery
