摘要
目的:评价黄体酮治疗先兆流产对围生儿结局的影响。方法:分析2002年1月到2006年6月四川大学华西第二医院产科收治的410例单胎早期先兆流产患者(治疗组)的围生儿结局,随机选取同期该院410例无早期先兆流产孕妇(对照组)的围生儿结局进行对照。结果:黄体酮治疗组与对照组相比,活产儿数、活产儿性别、出生体重、出生身长、1分钟Apgar评分≤7分所占比例差异无显著性(P>0.05);难免流产、死胎、早产的发生率以及早产儿结局差异亦无显著性(P>0.05);围生儿畸形治疗组12例(2.93%),对照组11例(2.68%),两组差异无显著性(P>0.05)。治疗组复发性流产发生率6.25%。治疗组中,单独使用黄体酮及黄体酮联合其他保胎药治疗的围生儿结局比较差异无显著性(P>0.05)。结论:先兆流产患者早期、足量、规律使用黄体酮,可以改善围生儿结局;该研究范围内不支持黄体酮治疗先兆流产会增加围生儿畸形的发生率,但仍需扩大样本长期随访。
Objective：To evaluate the effect of progesterone administration on the perinatal outcome in treatment of threatened abortion. Methods：410 perinatal outcome of threatened abortion which were treated with progesterone （the treat group） and 410 without progesterone （the control group）in the Department Of Obstetrics , West China Second University Hospital from January,2002 to June,2006 were analyzed by open and prospective controlled clinical trail. Results：There were no statistically significant differences of the perinatal outcomes between the treat group and the control group,and also no differences between the single and multiple regimen. The incidence of the recurrent abortion in treat group was 6.25% .The incidence of abnormality in the two groups were 2.93% and 2.68%, respectively, there was no statistically significant difference （ P 〉 0.05）. Conclusions： Treatment to threatened abortion by progesterone immediately, enoughly, and regularly can improve the perinatal outcome. Our research showed no definitely evidence to support the conclusion of administration of progesterone would increase the incidence of perinatal abnormality which still needs iong-time follow-up and large sample study.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2008年第3期156-159,共4页
Journal of Practical Obstetrics and Gynecology
关键词
黄体酮
先兆流产
围生儿结局
Progesterone
Threatened abortion
Perinatal outcome
