摘要
目的测定阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并肺动脉高压(pH)患者血浆肾上腺髓质素(adrenomedullin,ADM)、内皮素-1(ET-1)水平,并探讨其临床意义。方法选2002年3月至2004年10月在郑州大学第一附属医院经多导睡眠仪监测诊断的58例OSAHS患者,分为单纯OSAHS组、OSAHS并pH组,选取30名健康体检者为正常对照组。检测各组血浆ADM、ET-1水平、RVPEP/AT、AHI、minSaO2及TSaO2水平,并进行相关性分析。结果单纯OSAHS组及OSAHS并pH组血浆ADM、ET-1水平[ADM:(54.19±11.60)pg/ml,ET-1:(52.2±8.96)pg/ml;ADM:(79.82±15.33)pg/ml,ET-1:(79.3±11.25)pg/ml]均高于正常对照组[ADM:(44.73±8.52)pg/ml,ET-1:(37.4±9.85)pg/ml,P<0.01];OSAHS并pH组又高于单纯OSAHS组(P<0.01)。经nCPAP治疗后OSAHS并pH患者血浆ADM、ET-1水平明显降低[ADM:(79.82±15.33)pg/ml,ET-1:(79.3±11.25)pg/ml;ADM:(63.48±10.76)pg/ml,ET-1:(62.4±8.23)pg/ml,P<0.01〗,血浆ADM水平始终与ET-1、RVPEP/AT、AHI、TSaO2呈正相关,与minSaO2呈负相关。结论ADM、ET-1可能参与了OSAHS患者pH的发生发展过程。
Objective To study the plasma levels of adrenomedullin （ADM） and endothelin-1 （ ET-1 ） in patients with obstructive sleep apnea- hypopnea syndrome （OSAHS） incorporating pulmonary hypertension （pH） and their significance in the development of pH. Methods Fifty-eight patients with OSAHS were divid- ed into pure OSAHS group and OSAHS incorporating pH group. Thirty healthy subjects served as a normal control group. The plasma ADM and ET-1 levels, RVPEP/AT, AHI, minSaO2 and TSaO2 were measured and the correlation analysed. Results The plasma ADM and ET-1 levels in pure OSAHS group [ ADM： （54. 19 ± 11.60） pg/ml , ET-1 ： （52.2 ± 8.96） pg/ml ] and OSAHS incorporating pH group [ ADM ： （ 79.82 ±15.33 ） pg/ml, ET-1 ： （79. 3±11.25 ） pg/ml] were both significantly higher than those in controls [ ADM ： （44. 73 ＋ 8. 52） pg/ml, ET-1 ： （37. 4±9. 85） pg/ml] （P 〈0.01 ） and the plasma ADM and ET-1 levels in OSAHS incorporating pH group were higher than those in pure OSAHS group （ P 〈 0. 01 ）. The plasma ADM and ET-1 levels in patients with OSAHS incorporating pH[ ADM： （79.82 ± 15.33 ） pg/ml, ET-1 ： （79. 3 ± 11.25） pg/ ml ; ADM ： （ 63.48± 10. 76） pg/ml, ET-1 ： （62. 4 ＋ 8. 23 ） pg/ml, P 〈 0. 01 ] were significantly decreased after nCPAP treatment. Moreover, the plasma ADM levels were positively correlated with ET-1, RVPEP/AT, AHI,TSaO2 and negatively correlated with minSaO2. Conclusion ADM and ET-1 may take part in the development of pH in patients with OSAHS.
出处
《中国实用医药》
2008年第12期37-39,共3页
China Practical Medicine
