摘要
目的观察奥卡西平（OXC）治疗儿童局限性癫癎的疗效和不良反应,并作出评价。方法局限性癫癎患儿64例,41例新诊断或未经正规抗癫癎治疗需用OXC单药治疗的患儿进入OXC单药治疗组;23例曾使用一种或多种抗癫癎药物治疗,目前仍需联合应用OXC进行抗癫癎治疗的患儿进入OXC添加治疗组。OXC治疗的起始剂量为4～8 mg/（kg·d）,每隔1周增加1次剂量,每次增加不超过10 mg/（kg·d）,维持剂量28～40 mg/（kg·d）,分2次服用。进行自身对比开放性观察,分析二组6个月内的疗效及不良反应。结果本组中单药治疗组、添加治疗组、全组的总有效率分别为85.4%、69.6%、79.7%,其完全控制率分别为53.7%、17.4%、40.6%。单药治疗与添加治疗组6个月后总有效率比较有显著性差异（P〈0.05）;单药治疗组2、4、6个月总有效率比较无显著性差异（Pa〉0.05）。最常见的不良反应：皮疹7例,嗜睡、头晕各3例,乏力2例,低钠血症、恶心纳差各1例。因皮疹退出6例（9.4%）,停药及对症处理后,均恢复正常。结论OXC治疗儿童局限性癫癎疗效确切、耐受性好、不良反应轻。
Objective To evaluate the efficacy and adverse events of oxcarbazepine（OXC） on the children with partial epilepsy. Methods Sixty - four children with partial epilepsy were divided into 2 groups. Forty - one newly diagnosed patients who had never accepted standard therapy entered monotherapy group, and 23 patients who had many anti -epileptic drug（AEDs） in turn with poor efficacy served as add -on therapy group. The initial dose was 4 -8 mg/（ kg·d）. The dosage was increased by one time every 2 weeks, and should not exceed 10 mg/（ kg·d） in each time. The maintenance dose was 28 - 40 mg/（ kg·d ）. With open - label autocontrol method, the efficacy and adverse events of OXC were analyzed during the first 6 months of treatment both in 2 groups. Results The effective rates were 85.4% ,69.6% and 79.7% ,in monotherapy,add -on therapy and total groups. The seizure free rates were 53.7% ,17.4% and 40.6%. It showed that the seizure frequencies between 2 groups at 6 months after therapy were significantly difference（ P 〈 0.05 ）. However,there were no signi-fieantly differences at 2,4 and 6 months after therapy in monotherapy group（Pa 〉 0.05 ）. The common adverse events were dizziness,headache,fatigue and nausea. SIX patients had dropped out because of rashes,however, they all recovered after drug withdrawal and nonspeeific therapy. Conclusion The efficacy of OXC is sustained with good safety and tolerability profiles on the treatment of children patients with partial epilepsy.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第7期537-538,共2页
Journal of Applied Clinical Pediatrics
关键词
奥卡西平
癫癎
局限性
疗效
不良反应
儿童
oxcarbazepine
epilepsies, partial
efficacy
adverse events
child
