摘要
The X protein （HBx） of Human hepatitis B virus （HBV） acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the deve!opment of Hepatocellular carcinoma （HCC）. Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors （COX-2 and iNOS）, oncoprotein （Ras）, and a newly identified tumor suppressor （YueF）. The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
The X protein (HBx) of Human hepatitis B virus (HBV) acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the development of Hepatocellular carcinoma (HCC). Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors (COX-2 and iNOS), oncoprotein (Ras), and a newly identified tumor suppressor (YueF). The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
基金
the Major State Basic Research Development Program of China("973"project No.2005CB52290and No.2005CB522905)
The National Natural SciencFoundation of China(No.30470087and No.30730001)
ThDepartment of Science Technology of Hubei Province(No2005S2354)
Program for Changjiang Scholars anInnovative Research Team in University(PCSIRT)
