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CD44v6和VEGF在肝细胞肝癌中的表达及意义 被引量：2

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摘要 目的研究血管内皮生长因子(VEGF)和黏附分子(CD44v6)在肝细胞肝癌中的表达,及其与肝癌病理生物学行为之间的关系。方法采用免疫组化方法检测40例肝癌手术切除标本的VEGF及CD44v6的表达情况。结果①CD44v6和VEGF在肝癌组织中阳性表达率分别为58.5%和77.5%,明显高于在正常肝组织中其阳性表达率,均P<0.01,差异有显著性。②VEGF与肿瘤的转移、肿瘤的大小呈正相关,与肝癌组织分化程度无关;③CD44v6与肿瘤的转移、分化程度呈正相关,与肿瘤的大小无关,④CD44v6蛋白与VEGF蛋白在肝癌中的表达有相关性(r=0.506,P<0.01)。结论CD44v6和VEGF在肝癌组织中的表达均与肝癌的浸润转移有关,提示同时进行CD44v6和VEGF的检测对于评估肝癌的预后有一定意义。
作者 高爱社 李瑞琴 李建国
机构地区 河南中医学院病理与病理生理学教研室
出处 《广东医学》 CAS CSCD 北大核心 2008年第5期803-805,共3页 Guangdong Medical Journal
基金 河南中医学院科研苗圃工程项目(编号:MP2007-12)
关键词 肝癌 CD44V6 VEGF 免疫组织化学 预后
分类号 R735.2 [医药卫生—肿瘤] R734.2 [医药卫生—肿瘤]
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参考文献10

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共引文献4

同被引文献63

  • 1潘小季,孙维佳,欧阳建怡.胰腺癌中DPC_4/Smad_4、nm23-H_1/NDPK的表达及其意义[J].中国医师杂志,2005,7(4):454-456. 被引量：2
  • 2白纪刚,吕毅,王浩华.仓鼠胰腺癌原位模型的建立及生物学特性[J].第四军医大学学报,2005,26(24):2216-2218. 被引量：5
  • 3李梅,王芳,费继敏.nm23基因与肿瘤侵袭转移的相关性研究[J].实用癌症杂志,2006,21(1):90-92. 被引量：3
  • 4张煜,徐涵文,张太平,张鹤云.注射法制作ICR小鼠肝癌模型及其改进[J].细胞生物学杂志,2007,29(3):434-438. 被引量：6
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引证文献2

二级引证文献8

广东医学
2008年 第5期

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