摘要
目的探讨肾原发性类癌的组织学发生、临床病理特征、鉴别及预后。方法对1例原发于肾的类癌进行光镜、免疫组化和超微结构研究,并复习相关文献。结果患者男性,46岁。CT显示肿块边界尚清,均质,增强后肿瘤强化不明显。光镜下肿瘤组织呈梁状、缎带状排列,间质富于薄壁血管;肿瘤细胞多边形,胞质嗜酸,细胞界限不清,核圆,核分裂少见。免疫表型:肿瘤细胞Syn、CD99和vimentin(+),CKpan、EMA、CK7、CD10、P504S、Ksp-cadherin、CD117、SMA和CD34(-)。电镜下肿瘤细胞胞质内见大量神经分泌颗粒,细胞间还可见桥粒结构。结论肾原发性类癌是一种罕见的肿瘤,诊断主要依据病理形态学检查和免疫组化标记,电镜检查有助于确定诊断。
Purpose To investigate the clinicopathological features, histogenesis, and prognosis of primary renal carcinoid tumor. Methods One case of primary renal carcinoid tumor was studied histologically, ultrastructumlly and immunohistochemically. Results The patient was a 46-year-old man. The tumor was well-circmnscribed and appeared with minimal or poor enhancement on contrast enhanced CT scan. Histologically, predominant histological pattern of carcinoid tumor of the kidney showed a trabecular or ribbon-like arrangement admixed with solid nests within highly vascularized stroma. Tumor cells were largely polygonal with granular eosinophilic cytoplasm and indistinguishable cytoplasmic boundaries. Nuclei were round to oval and uniform in size with rare mitotic figures. Immunohistochemically, the tumor strongly expressed Syn, CD99 and vimentin, and negative for CK-pan, EMA, CK7, CD10, PS04s, Ksp-cadherin, CD117, SMA and CD34 in this case. Under the electron microscope, the tumor cells were rich in round, cytoplasmic granules of electron density with intercellular junctions. Conclusions Primary renal carcinoid tumor is an uncommon tumor, and its diagnosis could be established on the pathologic characteristics, immunoreactivity for neuroendecrine markers. Electron microscopy is helpful to confirm the diagnosis and differential diagnosis.
出处
《诊断病理学杂志》
CSCD
2008年第2期111-113,共3页
Chinese Journal of Diagnostic Pathology
关键词
肾细胞癌
类癌
免疫组化
超微结构
影像学
Renal carcinomas
Careinoid
Immunohistochemistry
Uhrastructttre
Imaging
