摘要
目的探讨老年难治性原发性高血压患者粥样硬化性肾动脉狭窄(ARAS)的患病率及其相关危险因素,为老年难治性原发性高血压及肾动脉狭窄的防治提供理论依据。方法对258例60岁及以上老年难治性原发性高血压患者,其中男187例,女71例,对其肾动脉超声检查结果进行分析,并对其相关危险因素与ARAS之间的关系进行单因素和多因素Logistic回归分析。结果258例老年难治性原发性高血压患者,平均年龄(73.4±7.7)岁,共检出ARAS患者75例,患病率为29.1%。单因素分析表明年龄、男性、外周动脉疾病、高脂血症、脑血管疾病、冠心病是ARAS的危险因素。多元Logistic回归分析表明,高脂血症(OR=1.928,P<0.05)及外周动脉疾病(OR=2.058,P<0.05)是ARAS的独立预测因素。结论老年难治性高血压人群中肾动脉狭窄患病率为29.1%,年龄、男性、外周动脉疾病、高脂血症、脑血管疾病、冠心病是合并ARAS的潜在危险因素,外周动脉疾病及高脂血症为ARAS的独立相关危险因素。
Objective To investigate the prevalence and related risk factors of atherosclerotic renal artery stenosis （ARAS） in elderly patients with refractory primary hypertension so as to provide theoretical basis for prevention and cure of the disease. Methods Renal artery uhrasonograph in 258 elderly patients （over 60 years old, male 187, female 71） with refractory hypertension was analyzed. Univariate and multivariate logistic regression analyses were carried out to analyze the relationship between risk factors and ARAS. Results Of 258 patients, ARAS was found in 75 patients （29.1%）. Univariate analysis showed that age, male, peripheral arterial disease, hyperlipidemia, eerebrovaseular disease and coronary heart disease were associated with atheroselerotie renal artery stenosis. Multivariate regression analysis showed that hyperlipidemia （OR = 1. 928, P 〈 0.05） and peripheral arterial disease （OR = 2. 058, P 〈 0.05） were independently correlated with atherosclerotic renal artery stenosis. Conclusion The prevalence of ARAS is 29.1% in elderly patients with refractory hypertension. Age, male, peripheral arterial disease, hyperlipidemia, cerebrovascular disease and coronary heart disease were potential related risk factors, and hyperlipidemia and peripheral arterial disease were independent risk factors.
出处
《解放军预防医学杂志》
CAS
北大核心
2008年第2期93-96,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
难治性高血压
动脉粥样硬化
肾动脉狭窄
refractory hypertension
atherosclerosis
renal artery stenosis
