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(S)-4-(4-氨基苄基)-2-噁唑烷酮的合成

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摘要 目的:改进(S)-4-(4-氨基苄基)-2-噁唑烷酮的制备方法。方法:以L-苯丙氨酸为原料,经过硝化、酯化、还原(酯)、还原(硝基)和环合共五步反应合成抗偏头痛药物佐米曲普坦的重要中间体(S)-4-(4-氨基苄基)-2-噁唑烷酮。结果:目标产物经熔点测定、1HNMR及MS-EI确证其化学结构,总收率为39.3%。结论:改进后的工艺,反应条件温和,操作简便,对环境污染较少。
出处 《黑龙江医药科学》 2008年第2期62-63,共2页 Heilongjiang Medicine and Pharmacy
基金 徐州医学院科研基金项目(07KJ54)
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