摘要
目的:探讨普罗帕酮不良反应发生的特点及一般规律,为临床安全用药提供参考。方法:采用回顾性研究方法,对1994—2007年国内医药期刊报道的366例普罗帕酮致不良反应病例进行统计、分析。结果:普罗帕酮所致不良反应男性多于女性,并在高年龄组发生比例高。不良反应临床表现复杂多样,尤以心血管系统所占比例最高,其次为肝肾系统。结论:临床医师、药师应加强对普罗帕酮的用药指导及监测,以避免不良反应的发生。
OBJECTIVE To study the general pattern and characteristics of adverse drug reaction caused by propafenone. METHODS A retrospective study was carried out, with collection, statistic and analyses 366 cases of adverse drug reactions induced by propafenone reported in domestic journals during 1994-2007. RESULTS At the ADR cases induced by propafenone, male ratio was higher than females, and the ADR were more often seen in aged group. Multi - systems were involved in adverse drug reactions, and the clinical manifestations were various, dealing with the cardiovascular system showing the highest proportion, then the hepatobiliary system and kidney. CONCLUSION Clinic doctors and pharmacists should give more directions and monitoring to avoid the occurrence of serious adverse drug reactions.
出处
《天津药学》
2008年第2期29-30,80,共3页
Tianjin Pharmacy
关键词
普罗帕酮
不良反应
回顾性分析
propafenone, adverse drug reaction, retrospective analysis
