摘要
目的研究和评价谷氨酰胺对慢性阻塞性肺疾病(COPD)急性加重期老年患者营养状况和免疫功能的影响。方法对52例急性加重期COPD患者进行营养支持治疗,分为:谷氨酰胺治疗组(G lu组26例),在常规治疗的基础上口服L2谷氨酰胺10 g,每天3次,连续10 d;常规组(26例),采用常规治疗。结果治疗后G lu组肱三头肌皮褶厚度、上臂肌围长、血浆总蛋白、血清白蛋白、前白蛋白、转铁蛋白营养参数较常规组明显改善。G lu组中IgG、IgA、CD3、CD4、CD4/CD8免疫指标明显升高(P<0.05),与常规组相比有统计学意义(P<0.05)。结论G lu对COPD急性加重期老年患者不仅有营养支持作用,并具有免疫增强作用。
Objective To investigate the efficacy of oral glutamine supplementation therapy in elderly patients with acute exacerbating chronic obstructive pulmonary disease （COPD）. Methods Fifty-two patients with COPD were randomly assigned to glutamine （ Glu group, n = 26 ） or control group （ n = 26 ）. The patients in the Glu group received 10-day oral L-glutamine （ 10 g/day,three times daily）. The patients in the control group only received routine nutrition. Results The triceps skin fold thickness,midarm circumference,serum total protein,albumin,preal- bumin and transferrin of the patients were improved after the treatment with glutamine. Compared to the control group, patients in the Gin group had a higher levels of IgG, IgA, CD3, CIM, and CIM/CDS. The immune parameters of the Gin group were statistically increased than those of the control group. Conclusions This study indicates that gluta- mine supplementation can serve as a nutritional support therapy for the elderly patients with acute exacerbation COPD. moreover, this therapy may improve the immunity of the patients.
出处
《中国临床保健杂志》
CAS
2008年第2期113-115,共3页
Chinese Journal of Clinical Healthcare
