辛伐他汀对STZ-糖尿病大鼠骨代谢指标及骨密度影响的实验研究被引量：8

The effects of simvastatin on bone metabolism indexes and the bone mineral density in STZ induced-diabetic rats

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摘要目的观察辛伐他汀对糖尿病大鼠血、尿I型胶原变联氨基末端肽(NTX)以及骨密度的影响,以了解他汀类药物对糖尿病性骨质疏松是否存在保护作用。方法健康雄性2月龄Wistar大鼠24只,体重(200±20)g,分为健康对照组(A组)、糖尿病组(B组)、辛伐他汀治疗组(C组)每组各8只。建立糖尿病大鼠模型后,检测各组第2周及第8周血糖、NTX,于第8周末处死大鼠,测定血NTX、全身骨密度及双侧股骨骨密度。结果第8周B组、C组骨密度较A组明显减低,C组经辛伐他汀治疗8周后骨密度较B组有所增加(P<0.05);B组和C组血、尿NTX显著高于A组(P<0.01);C组血、尿NTX低于与同期B组(P<0.05)。结论辛伐他汀对糖尿病大鼠骨质疏松存在一定程度的保护作用。 Objective To evaluate the effects of simvastatin on bone metabolism by measuring bone turnover markers NTX and bone mineral density（BMD） in STZ-induced diabetic rats. Methods 24 Wistar rats were randomly assigned to normal control group （ group A, n = 8 ） ,diabetic rats group （ group B, n = 8 ） and simvastatin （ 20 mg· kg^-1· d^-1） treatment diabetic group （group C, n = 8）. Urinary NTX were tested at the 2nd,8th week. Blood NTX and BMD were tested at the 8th week. Results ①At the 8th week, BMD in group B and C were lower than that of group A（P 〈0. 01 ）. BMD in group C was higher than that in group B（P 〈0. 05） ;serum NTX at the 8thweek and urinary NTX in group B,C at the 2th and 8th weeks were higher than those of group A（P 〈0. 01 ） ,while serum and urinary NTX in group C decreased significantly compared with those in group B （ P 〈 0. 05 ）. Conclusion Simvastatin could play a rote in the development of asteoporosis in diabetic rats.

作者苏晓燕邢学农陈燕杨光伟叶山东

机构地区安徽医科大学附属省立医院安徽省立医院内分泌科

出处《中国临床保健杂志》 CAS 2008年第2期178-180,225,共4页 Chinese Journal of Clinical Healthcare

关键词糖尿病实验性辛伐他汀骨质疏松骨密度大鼠 Diabetes mellitus, experimental Simvastatin Osteoporosis Bone density Rats

分类号 R587.1 [医药卫生—内分泌]

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参考文献9

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