摘要
目的探讨母亲怀孕前后被动吸烟与子代发生神经管畸形（NTD）危险性的关系。方法资料来源于北京大学生育健康研究所在山西省平定、昔阳、太谷和泽州4个县开展的以人群为基础的出生缺陷病例对照研究。病例为2003年1月到2007年6月监测到的515例NTD病例（其中无脑儿236例，脊柱裂237例，脑膨出42例），对照组为同期在同地区调查的682例无体表出生缺陷的婴儿。研究人员在妇女分娩一周内问卷调查妇女怀孕前后的被动吸烟及其他信息。用非条件logistic回归模型调整混杂因素。结果与无被动吸烟的妇女相比，怀孕前后有被动吸烟的妇女生育NTD的危险性（OR值）为1．84（95％CI：1．39～2．44）。妇女被动吸烟频度与子代发生NTD危险性之间存在显著的剂量反应关系。与无被动吸烟的妇女相比，偶尔有被动吸烟的妇女和每天有被动吸烟的妇女生育NTD的OR值分别为1．51和2．44（趋势Х^2=24．9，P〈0．001）。结论妇女怀孕前后被动吸烟增加生育NTD患儿的危险性。
Objective To explore the relationship between maternal passive smoking during early pregnancy and the risk of neural tube defects （NTDs）. Methods Data was derived from a population- based case-control study on birth defects in Shanxi province. The study subjects included 515 NTDs defects cases （236 cases of anencephaly, 237 spina bifida and 42 encephalocele） ascertained during January 2003 and June 2007 in the study areas and 682 normal controls randomly selected in the same residence during the same period as cases. Results The risk of NTDs in their offspring was 1.84 （95 % CI ： 1.39-2.44） for mothers with passive smoking history during peri-conceptional period. There was a marked dose-response relation between maternal passive smoking and the risk of NTDs in offspring. Compared to the women without passive smoking, the NTDs risk in offspring was 1.51 for women with occasional passive smoking and 2.44 for women with passive smoking for almost everyday during the peri-conceptional period. Conclusion Maternal passive smoking during peri-conceptional period increased the risk of NTDs in offspring.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2008年第5期417-420,共4页
Chinese Journal of Epidemiology
基金
国家“十五”科技攻关课题资助项目（2002BA709B11）
中美出生缺陷病因研究合作项目（S040059）.本研究现场工作得到了山西省卫生厅妇幼保健与社区卫生处、山西省平定县妇幼保健院、昔阳县妇幼保健院、太谷县妇幼保健院和泽州县妇幼保健院的大力支持,谨此志谢
关键词
出生缺陷
神经管畸形
吸烟
被动吸烟
病例对照研究
Birth defects
Neural tube defects
Tobacco smoking
Passive smoking
Case-control study
