摘要
目的观察加强水化/碱化措施对造血干细胞移植(HSCT)患者急性出血性膀胱炎(HC)的预防效果。方法82例以环磷酰胺(CTX)为主进行预处理的HSCT患者,随机分为两组,传统模式组52例患者采用传统的水化/碱化模式,强化模式组30例患者采用强化水化/碱化模式预防急性HC,比较两种模式预防HC的效果。结果传统模式组52例患者中有8例发生急性HC,发生率为15.1%,强化模式组30例患者中,无1例发生HC,两组HC发生率比较差异有统计学意义(P<0.05);临床观察发现强化模式组患者心率波动较小,血钾及血钙浓度持续稳定时间较长。结论强化水化/碱化模式明显降低HSCT患者HC的发生率,且临床应用安全可靠。
Objective To investigate the acute hemorrhagie cystitis（HC） prevention effect of intensified diuresis and alkalinizing in hematopoietic stem cell transplantation （HSCT） patients. Methods Eighty two HSCT patients treated with conditioning regimens containing cyclophosphamide （CTX）were divided into 2 groups. The patients in intensified group used intensified mode of diuresis and alkalinizing, while patients in classical group used classical mode of diuresis and alkalinizing to prevent acute HC, then the occurrence frequency of HC between the 2 groups was compared. Results Eight of the 52 patients used classical mode developed HC and no patient developed HC in 30 patients used intensified mode. The incidence of HC had significantly difference between the two groups（P 〈 0. 05）. It was found that the heart rate of patients in intensified mode group fluctuated less than that in classical mode group, and the stabilization time of kalium concentration and calcium in intensified group was longer than those in classical mode. Conclusion The intensified mode of diuresis and alkalinizing can decrease the ineidence of HC and it is safe in clinical application.
出处
《国际内科学杂志》
CAS
2008年第4期187-189,共3页
International Journal of Internal Medicine
关键词
出血性膀胱炎
水化/碱化
造血干细胞移植
Hemorrhagic cystitis
Diuresis and alkalinizing
Hematopoietic stem cell transplantation
