摘要
目的观察血脂康在老年高血压患者降压治疗中对血压和脉压的影响。方法将经氨氯地平（5mg，1次／d）降血压治疗后达到轻度高血压标准的老年高血压患者58例随机分为两组，血脂康组30例和对照组28例。对照组采用低脂、低盐饮食及按原剂量服用氨氯地平；血脂康组在此基础上加用血脂康600mg，2次／d，连续服用12周，比较两组治疗前与治疗12周时血压和脉压的变化。结果与治疗前比较，血脂康组治疗12周收缩压降低，分别为（149±9）mmHg与（130±8）mmHg；脉压缩小，分别为（64±11）mmHg与（48±7）mmHg（均为P〈0．05）；12周时组间比较，血脂康组优于对照组，收缩压分别为（130±8）mmHg与（144±9）mmHg，脉压为（48±7）mmHg与（60±10）mmHg（均为P〈0．05）。结论老年高血压患者降压治疗中，应用常规剂量血脂康治疗可以起到降低血压的作用效应。
Objective To investigate the effect of Xuezhokang treatment on blood pressure and pulse pressure （PP） of elderly patients with primary hypertension （PH）. Methods Fifty-eight elderly PH patients were treated with Amlodipine（5 mg/d）. After the blood pressure were decreased to mild hypertension level, all the patients were randomly divided into 2 groups： 30 patients in the Xuezhikang group, and 28 patients in the control group. The patients in the control group were treated with low fat and low salt diet and Amlodipine as before, and the patients in Xuezhikang group were treated not only with Xuezhikang 300 mg twice a day and Amlodipine as before for 12 weeks. Results The SBP and PP （mm Hg） were improved in both Xuezhikang and control groups, and Xuezhikang showed a better therapeutic effect（P〈0.05）than did the control. Xuezhikang group had SBP of （149±9, pretreatment） and （130 ± 8, posttreatment）, and PP of （64 ± 11, pretreatment） and （48±7, posttreatment） （all P〈0.05）. Control group showed SBP of （144±9） and （130±8） in pre- and post-treatment respectively, and showed PP of （60 ±10, pre-Rx） and （48 ± 7, post-Rx） （all P〈0. 05）. Conclusions Anti-hypertensive medications in a routine dose combined with Xuezhikang have a better effect on the hypertension treatment in elderly patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2008年第4期259-261,共3页
Chinese Journal of Geriatrics
