摘要
群体药物代谢动力学(PPK)在西方国家已有将近40年的发展和应用历史,越来越广泛地用于临床合理用药和个体化给药中。本文简要介绍了PPK基本原理,求算PPK参数的有关方法,重点阐述了目前较常应用的非线性混合效应模型法,并列举了群体药物代谢动力学在常规治疗药物监测、个体化给药以及上市前新药研究中的应用实例。
Population pharmacokinetics has been developed and applied for tens of years in many western countries, However,it is much less applied in China. This article mainly introduced the fundamental principle of population pharmacokinetics （PPK）, some routine methods to estimate the parameters of PPK and their advantages and disadvantages, and emphasized the methods for nonlinear mixed effects modeling ,which is widely used currently. Finally,we gave some examples for use of PPK in the area of therapeutic drug monitoring （TDM）, the use of PPK in individualization regime, and in population analysis of the medicine which has just come into the market.
出处
《医学综述》
2008年第9期1394-1397,共4页
Medical Recapitulate
