摘要
E-选择素表达于受细胞分裂素刺激后内皮细胞表面,也主要集中于毛细血管后微静脉。其配体是唾液酸化的路易斯寡糖或类似结构的分子,在中性粒细胞、嗜酸性粒细胞和正常骨髓前体细胞上大量表达。E-选择素具有内皮特异性,因此外周血中的可溶性E-选择素可作为内皮细胞激活的特异性指标。现就细胞黏附分子中的E-选择素与心血管疾病、糖尿病、变态反应疾病等症的研究进展予以综述。
E-selectin finds its expression in endothelial cell surface stimulated by the acytokinin, mainly in the post-capillary venules. Its ligand is sialyl Louis oligosaccharides or similar molecular structure, and expresses in neutrophils, eosinophils and normal bone marrow precursor cells. E-selectin is an endothelial-spe- cific in the peripheral blood of a soluble, so it can be used as specific indicators in endothelial cell activation. The article gives an overview about the relationship between E-selectin in cell adhesion molecule and cardio- vascular disease, diabetes, and allergic diseases.
出处
《医学综述》
2008年第9期1411-1413,共3页
Medical Recapitulate
