摘要
目的:探讨原发性高血压病患者尿液中β_2-微球蛋白(β_2-MG)与尿微量白蛋白(mALB)和尿转铁蛋白(UTRF)的关系。方法:采用免疫比浊法检测尿β_2-MG、mALB和UTRF。结果:mALB和β_2-MG之间有显著的正相关关系(F=0.5(?),p<001),mALB和UTRF之间有显著的正相关关系(F=0.791,p<0.001),UTRF和β_2-MG之间有显著的正相关关系(F=0.54,p<0.001);单因素Linear Regression分析发现UTRF是mALB和β_2-MG的相关因子(p<0.001)。结论:UTRF升高的高血压病患者,mALB和β_2-MG均增加,UTRF、mALB和β_2-MG的测定可作为高血压患者早期肾损伤的一个理想的反应肾小球滤过功能的敏感指标。
Objective： To discuss relationship between transfemn （UTRF） β2-microglobulin （β2-MG） and microalbminuria （mALB） in patients with hypertension. Method： Detectd turbidity β2-MG,mALB and UTRF in urine by immunoturbidimetrical method. Results： Significantly positive correlations were observed between UTRF and β2-MG （ F=0.507, p〈0.001）, mALB and UTRF （ F=0.791, p〈0.001 ）, UTRF and β2-MGbetween （F=0.554, p〈0.001 ）, respectively. Single factor Linear Regression analysis showed that UTRF was a related factor ofmALB and β2- MG （p〈0.001）. Conclusion： MALB and β2-MG were increased with the enhance of UTRF in patients with hypertension,, UTRF, mALB and β2-MG determination could be used as sensitive and ideal indicators for estimation of glomerular filtration rate during the early kidney damage in patients with hypertension.
出处
《现代生物医学进展》
CAS
2008年第7期1299-1301,共3页
Progress in Modern Biomedicine
