摘要
动脉粥样硬化是最重大的疾病之一,是心脑血管病的主要病理基础,严重危害人类健康。近年来的研究表明,清道夫受体在胆固醇代谢中起着重要作用。清道夫受体是一类结构多样化的糖蛋白受体,具有广泛的配体谱和功能。已知清道夫受体与动脉粥样硬化、宿主防御、细胞粘附、细胞增殖以及细胞凋亡等均有不同程度的关系。文章就近几年来有关该受体的结构、分布、表达调控及其在动脉粥样硬化中作用作一综述,以探索防治途径。
Atherosclerosis is one of the most serious diseases, which is main pathobolism ofcerebrovascular diseases. It seriously harms human＇s health. Recent researches showed that scavenger receptor played an important role in the metabolism of cholesterol. Scavenger receptor is a family of multiligand and multifunctional glucoprotein receptor that involves in atherogenesis, host denfense, cell adhension, cell proliferation and apoptosis. The article reviewed the structure, distribution, expression and regulation of scavenger receptor and its effectiveness in the atherosclerosis to search for the means of prevention and cure.
出处
《现代生物医学进展》
CAS
2008年第7期1365-1367,共3页
Progress in Modern Biomedicine
关键词
清道夫受体
动脉粥样硬化
LDL
Scavenger receptor
Atherosclerosis
LDL（ low density liooorotein ）
