摘要
δ-氨基酮戊酸光动力学疗法是一种非创伤性局部治疗技术，可特异性杀死病变细胞。近年研究表明，该疗法对靶细胞某些生物学特征的影响是重要作用机制之一。除非色素细胞性皮肤恶性肿瘤外，δ-氨基酮戊酸光动力学疗法的适应症逐渐扩展至癌前病变、病毒疣、痤疮、结缔组织病、光化性疾病等范围。升高温度、促溶剂、金属离子螯合物、电离子导入、脂质体载体等因素可促进其疗效。
δ-aminolevulinic acid （ALA）-based photodynamic therapy （PDT） is a noninvasive topical treatment choice that can selectively kill target cells. One important mechanism for its therapeutic effect is to influence some biological characteristics of target cells. Besides nonpigment cell malignant tumors of skin, ALA-PDT could be used in the treatment ofpremalignant lesions, viral warts, acne, connective tissue diseases, actinic skin diseases, and so on. Appropriate higher temperature, cosolvents, metal chelating agents, iontophoretic delivery and liposome vector may enhance the therapeutic effect of ALA-PDT.
出处
《国际皮肤性病学杂志》
2008年第3期152-154,共3页
International Journal of Dermatology and Venereology
关键词
氨基酮戊酸
光化学疗法
皮肤疾病
Aminolevulinic acid
Photochemotherapy
Skin diseases
